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Opioid use progressively will increase following bariatric surgical procedure, till 1 in 5 sufferers are utilizing prescription opioids. Credit score: Nicole Santo/UPMC Whereas the proportion of adults with extreme weight problems utilizing prescription opioids initially declines within the months after bariatric surgical procedure, it will increase inside a matter of years, ultimately surpassing pre-surgery charges of sufferers utilizing the possibly addictive ache drugs, in keeping with new analysis from a Nationwide Institutes of Well being (NIH)-funded multicenter examine led by the College of Pittsburgh Graduate Faculty of Public Well being. The findings -- which come from one of many largest, longest-running research of adults who underwent weight-loss surgical procedure -- point out that enhancements in obesity-related ache gained by means of bariatric surgical procedure will not be ample to counter the necessity for ache aid within the y

"In previous studies, we showed that young, female mice consuming a Western diet, high in fat, sucrose and high fructose corn syrup, not only gained weight, but also exhibited vascular stiffening consistent with obese premenopausal women," said Vincent DeMarco, Ph.D., a research associate professor of endocrinology at the MU School of Medicine and the lead author of the study. "Our current study sought to understand if linagliptin prevents cardiac stiffening caused by eating a Western-style diet." Linagliptin is a medication prescribed to lower blood glucose in patients with Type 2 diabetes. The medication works by blocking the enzyme dipeptidyl peptidase-4, or DPP-4. Previous studies have shown that DPP-4 inhibitors offer protection against vascular inflammation and oxidative stress -- conditions associated with cardiovascular stiffening. DeMarco's team studied 34 female mice that were fed either a normal diet or a simulated Western diet for four months.